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By M. Ian Phillips (Editor)

ISBN-10: 1588292053

ISBN-13: 9781588292056

ISBN-10: 1592598544

ISBN-13: 9781592598540

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2000) Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics. J. Clin. Invest. 106, 1197–1202. 39. 39 Lewin, A. , Drenser, K. , Hauswirth, W. , et al. (1998) Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa. Nat. Med. 4, 967–971. 40. 40 Lavail, M. , Matthes, M. , et al. (2000) Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy. Proc. Nat. Acad. Sci. USA 97, 11,488–11,493.

The peak MYC expression is followed by reduced but ongoing transcription and translation of c-myc mRNA that occurs simultaneously with the normal degradation of MYC protein. The expected result of a polymer-coated stent delivering AVI-4126 into the vascular wall will be to reduce the translation of c-myc mRNA. The rate of MYC degradation is not influenced, so the result will be observation of an enhanced rate of loss of MYC. Concern for lingering MYC expression influences duration for antisense present in the injured vessels.

A. (2003) Progress and prospects: naked DNA gene transfer and therapy. Gene Ther. 10, 453–458. 56. , et al. (2003) Structural variations and stabilizing modifications of synthetic siRNAs in mammalian cells. Nucleic Acid Res. 31, 2705–2716. 57. 57 Chiu, Y. L. and Rana, T. M. (2002) RNAi in human cells: basic structural and functional features of small interfering RNA. Mol. Cell 10, 549–561. 58. , Wiiger, M. , and Prydz, H. (2002) Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor.

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Antisense Therapeutics 2nd edition (Methods in Molecular Medicine) by M. Ian Phillips (Editor)

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