Allied Health Professions

New PDF release: Atherosclerosis and Heart Disease

By Andrew Tonkin

ISBN-10: 1841841234

ISBN-13: 9781841841236

Exploring the whole diversity of modern advances, Atherosclerosis and middle illness covers all facets of atherosclerotic ailment, together with continual manifestations, skip surgical procedure, stroke prevention and strategies to reduce blood strain. Professor Tonkin brings jointly a crew of internationally-recognized specialists to debate sound medical practices, in keeping with medical study and guides. They learn traditional and novel probability components, acute coronary syndromes, and persistent manifestations of disorder. The e-book offers a wide standpoint at the disorder method because it impacts the sufferers medical professionals see on a daily basis and descriptions present healing techniques.

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Additional info for Atherosclerosis and Heart Disease

Example text

Although we can glean much from the many epidemiological studies that have examined the relationship between lipid levels and risk of cardiovascular disease, it is perhaps more informative to look in detail at the largescale lipid-lowering trials. These studies set out to examine the impact of lipid-lowering drugs on the risk of major cardiovascular events in a wide variety of patient groups. In so doing they also set out to prove the lipid hypothesis, which states that an elevated plasma cholesterol level is causally associated with cardiovascular risk and that in lowering cholesterol we will reduce that risk.

30. Rodgers A, MacMahon S, Gamble G, Slattery J, Sandercock P, Warlow C, on behalf of the UKTIA Collaborative Group. Blood pressure and risk of stroke in patients with cerebrovascular disease. BMJ 1996;313:147. 31. Adler A, Stratton IM, Neil H, et al. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. BMJ 2000;321:412–19. BLOOD PRESSURE AND BLOOD PRESSURE - LOWERING THERAPY 32. UK Prospective Diabetes Study Group.

The primary endpoint was total mortality and Fig. 2 demonstrates that the mortality rates of the simvastatin and placebo groups began to diverge at around 18 months into the study and continued this trend throughout the period of the trial. 2 Major CHD Prevention Studies with Statins Clinical Trial Drug Used Number of Subjects Relative Reduction in Fatal or Non-fatal MI (%) West of Scotland Coronary Prevention Study (WOSCOPS) Cholesterol and Recurrent Events (CARE) Study Scandinavian Simvastatin Survival Study (4S) Long Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Air Force/Texas Coronary Prevention Study (AF/TEXCAPS) Heart Protection Study (HPS) Pravastatin Pravastatin Simvastatin Pravastatin Lovastatin Simvastatin 6595 4159 4444 9014 6605 20 536 –31 –24 –34 –23 –36* –24† * Expanded endpoint of combined unstable angina, fatal and non-fatal MI and sudden cardiac death.

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Atherosclerosis and Heart Disease by Andrew Tonkin


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