By Eric T. Wong
This concise textual content offers an entire assessment of alternating electrical fields treatment -- sometimes called tumor treating fields -- for glioblastoma and different varieties of stable tumor malignancies. Readers are given a primary figuring out of this novel anti-cancer remedy modality by way of studying from scientific trial info in addition to the actual and mobile biology results on tumor cells whilst alternating electrical fields are utilized either in vitro and in vivo.
Chapters illustrate the physics at the back of electrical box propagation in area and different media. this is often by means of a evaluation of our present realizing of the electrical box results on dividing cells - together with the disruption of cytokinesis, right chromosome segregation and activation at the telephone floor chaperons that set off immunogenic mobilephone dying. facts from part III trials for the remedy of recurrent and newly clinically determined glioblastomas are incorporated, in addition to many of the ancillary post hoc analyses that have been played by means of a number of investigators. the rest of the bankruptcy covers different sturdy tumor malignancies, together with non-small phone lung melanoma, pancreatic melanoma and ovarian melanoma, as this therapy modality is being utilized to systemic malignancies.
Alternating electrical Fields treatment in Oncology bargains oncologists, neurologists, radiation oncologists, biomedical engineers, telephone biologists and mitosis researchers the basics wanted for scientific practice.
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Extra info for Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields
This method relies on low-intensity, between 1 and 3 V/cm, and intermediate-frequency, between 100 and 300 kHz, alternating electric fields that have been shown in vitro and in vivo to destroy selectively dividing cells that are undergoing mitosis and cytokinesis [7, 13–15]. One assumed mechanism of action is an anti-microtubule effect whereby tubulin subunits are forced to align with the applied field, perturbing the formation of functional mitotic spindles that are essential for the completion of mitosis.
12]. , U m = j i - je , and the electric field distribution. Since the cell rounds up during mitosis [20, 21], it can be represented as a sphere with a very thin membrane with a thickness dm which separates the intracellular from the extracellular space (Fig. 1A). 1). The Effect of Frequency on the Electric Field During Metaphase If an alternating electric field of magnitude Ee is applied to the extracellular space, the magnitude of the resulting electric fields in the membrane, Em, and the intracellular space, Ei, are frequency dependent.
Kotnik T, Bobanović F, Miklavčič D. Sensitivity of transmembrane voltage induced by applied fields—a theoretical analysis. Bioelectrochem Bioenerg. 1997;43(43):285–91. 31. Kotnik T, Miklavčič D. Second-order model of membrane electric field induced by alternating external electric fields. IEEE Trans Biomed Eng. 2000;47(8):1074–81. 32. Hölzel R, Lamprecht I. Dielectric properties of yeast cells as determined by electrorotation. Biochim Biophys Acta. 1992;1104(1):195–200. 33. Gascoyne PR, Pethig R, Burt JP, Becker FF.
Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields by Eric T. Wong